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By G.D. Aurbach and Donald B. Mccormick (Eds.)

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DIT,facultative component of diettriiodothyronine; induced thermogenesis; M, full meal; NE, norepinephrine; RMR, resting metabolic rate; SNS, sympathetic nervous system; TS, -, not tested. 34 ETHAN A. H. SIMS give a quantitative estimate of the work done, extrapolation to zero of the plot of activity versus oxygen consumption can permit an estimate of the cost of activity above the resting metabolic rate. The subjects also wore pedometers and accelerometers on the nondominant wrist during the 3 weeks of the study.

Keesey (1980) recently reviewed the mechanisms whereby animals and man can maintain body weight within narrow limits. He pointed out that nothing appears to be wrong with the systems for regulation of body weight in lean animals with lesions of the lateral hypothalamus or in obese Zucker rats, but they do defend different weights. 75 power. Keesey suggested that human beings appear t o regulate weight around values that differ as much between individuals as between many species. Rapid regain of weight by the obese after dieting is all too frequent.

1985) does much to clarify the mechanism of diet-induced thermogenesis. To estimate whether energy balance or change in substrate traffic is the more important factor, a comparison was made between the response of six subjects taking, in random order for 6-day periods, either a maintenance diet, a diet increased in caloric content by 50% with sufficient exercise added to maintain basal weight, or the high-caloric diet without added exercise. Both overfed groups showed a significant increase in resting metabolic rate, but only those taking excess food alone showed a significant increase in free TBand insulin.

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